Did the Alien bastards not learn their lesson the first time? Duke has been on hiatus for some time now, kicking back and franchising himself on the fame he gained from saving Earth from the first invasion. The Aliens have returned to Earth yet again, messing up Duke's sweet routine of dirty leisure habits.
The Alien invaders are stealing Earth's women, especially the hot ones! And they drank Duke's beer. This. Won't. Stand. As Duke battles his way through waves of aliens, the once beautiful gambling haven and Duke Nukem franchise chains are crumbling before his eyes. Time to bring the pain!