Vampire Rain is a stealth-action game similar in nature to the Splinter Cell or Metal Gear Solid series. Players are tasked with navigating their character through city streets, while avoiding the vampire enemies that patrol the streets disguised as ordinary human citizens. Players will often have to take alternate routes, such as climbing onto rooftops or through alleys, to avoid enemy encounters.
Unlike most stealth-action games, Vampire Rain places heavy emphasis on pure stealth. Enemies are extremely fast and can kill the player in 1 or 2 hits. Additionally, for the first 1/3rd of the game, players lack any weaponry that can kill vampires effectively. Any attempt to initiate combat generally results in the player's death. Also, unlike most stealth games, there is no effective means to hide or escape once an enemy has spotted the player, which usually results in the player dying soon after being spotted.
Successful completion of many missions generally requires total avoidance of enemies by figuring out the correct route to pass through the mission area without being detected.
Later in the game, players are given high-powered weapons which prove more effective against the game's vampire enemies. Also, there are a few pre-scripted action sequences that involve fighting against multiple enemies, generally with the assistance of teammates or special environmental hazards. Your arensal includes a handgun, sub-machine gun, assault rifle, shotgun, sniper rifle, anti-armor rifle and a UV Knife used to stab an enemy from behind for an instant kill. On Xbox Live players may play as a nightwalker gaining all the advantages they had in the single-player but you may use UV Mines as traps to use against nightwalker opponents. Online multiplayer involves 8 players in standard modes like deathmatch, team deathmatch and capture the flame and the unique mode death or nightwalker which allows you to become a nightwalker and fight your opponents with extreme speed and power. All the firearms are available online and the gameplay is handled like the single-player. There are many other modes as well like Destroy.