Yakuza Kiwami is an action-adventure game with role-playing elements set in an open world environment and played from a third-person perspective. The player controls protagonist Kazuma Kiryu as he explores the streets of Kamurocho, a fictional district of Tokyo based on the real-life Kabukichō district. In addition to the main story, players will randomly encounter enemies on the street to battle, as well as meet people that will offer Kiryu side quests which can be completed for rewards.